13 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... organ damage • Treatment ... : • Pathophysiology ... #TLS #diagnosis ... #management #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... permeability Diagnosis ... CNS #neurology #rheumatology ... #management #treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... Imaging: CXR- pulmonary ... #management #hematology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Pathophysiology ... : Due to nerve root ... Guillain-Barre Diagnosis ... #diagnosis #management ... #treatment #neurology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diagnosis of ... irrigation • Management ... Torsemide) • Acute pulmonary ... • Nephrogenic diabetes ... Tolvaptan) • Treatment
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
symptoms • Rheumatologic ... Histoplasmosis Diagnosis ... MUCORMYCOSIS • Risk: Diabetes ... Aspergillosis Pathophysiology ... #Management #Infections
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... edema, compartment syndrome ... filling +++ (risk of pulmonary ... #diagnosis #management ... #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... Adenocarcinoma Treatment ... #Rheumatology # ... Diagnosis #Management
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
with thiazide diuretic ... Surreptitious diuretic ... Rhabdomyolysis Treatment ... #diagnosis #nephrology ... #management #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Pathophysiology ... Treatment Approach ... #Management #Hematology