25 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilic Syndrome ... Diagnosis and Treatment ... Matthew Ho, MD ... PhD @MatthewHoMD ... #HES #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... only curative treatment ... #MDS #Diagnosis ... #Management #treatment ... #hematology #oncology
Polyarteritis Nodosa (PAN) - Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Severe Disease → Remission
Polyarteritis Nodosa (PAN ... immunosuppressive agent (e.g ... Maheswaranathan, MD ... Vasculitis #Management #Treatment ... Guidelines #algorithm #rheumatology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Macroangiopathic, Infections ... aciduria, Drugs (e.g ... Reticulocytosis, MDS ... PhD @MatthewHoMD ... Differential #Diagnosis #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Diagnosis Algorithm Signs ... Hypersplenism, Infection ... Matthew Ho, MD ... PhD @MatthewHoMD ... Diagnosis #Algorithm #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... : • Recurrent infections ... megaloblastic anemia Treatment ... Can progress to MDS ... #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
drug reaction, infection ... glucocorticoid treatment ... organ-specific signs ... or symptoms (eg ... Differential #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
WBC >100k, + lab signs ... organ damage • Treatment ... Low calcium • Treatment ... unless worrisome EKG ... diagnosis #management #hematology
Approach to Headaches - Differential Diagnosis Algorithm

Red flags (PHANTOMS):
 • Pattern change, progressively worse, papilledema
 •
papilledema • Horner syndrome ... • Meningeal signs ... lesion • CNS infection ... Matthew Ho, MD ... PhD @MatthewHoMD