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diagnosis differential causes lupus management rheumatology druginduced sle thrombocytosis ckd comparison dil endocrinology erythematosus extravascular hemodialysis hemolysis hepatology intravascular lfts
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... Inflammatory: • IBD ... effect following treatment ... malignancy • Iron deficiency ... Differential #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... • PK deficiency ... perfringens - Complement-Mediated ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... Acute hemolysis, deficiency ... Rebound effect from treatment ... Differential #Diagnosis #Algorithm ... #hematology
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... suspicion for complement ... deficiency • Low ... #Algorithm #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... NAFLD • Others Mild ... • AIH • A1AT deficiency ... disease US — Normal ... Others #LFTs #Hepatology
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... Disease • GH Deficiency ... • IGF-I Deficiency ... Panhypopituitarism Treatment ... Celiac, IBD) •
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... Prognosis: Usually mild ... constitutional symptoms • Treatment ... 80% - Low complement ... life-threatening • Treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Malignancy (e.g. hematologic ... disease • Prolidase deficiency ... vein thrombosis Hematologic ... RNP antibodies, Complement
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
CRP - Usually normal ... 90% - Low complement ... Prognosis: Usually mild ... constitutional symptoms • Treatment ... #diagnosis #treatment
Management of Pruritus in Patients with Chronic Kidney Disease Pruritus with no primary lesions - differential diagnosis:
pruritus • Hematologic ... pruritus (Iron deficiency ... Use mild detergent ... #Pruritus #Treatment ... #Algorithm #Hemodialysis
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