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diagnosis differential hematology algorithm classification elevation oncology treatment acidosis approach b12 bacilliformis bartonella blood celiac chagas chronic cll coagulation cobalamin
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss • Acute ... Reticulocytes • Iron Deficiency ... • B12/Folate Deficiency ... Disease • Marrow ... Diagnosis #Algorithm #Causes
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... -12, or folate deficiency ... turnover • Acute ... • Hemolytic anemia ... End-stage renal disease
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
iron deficiency ... Test for celiac disease ... change medical management ... #Evaluation #workup ... #diagnosis #gastroenterology
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
suspected: • Signs ... • Iron-deficiency ... anemia unresponsive ... without discernable cause ... Diagnosis #Algorithm #gastroenterology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Infectious: • Acute ... disorders • Celiac disease ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... • Common Causes ... to IBD, celiac disease ... , PBS - anemia, ... #diagnosis #management
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Fever Hematologic disease ... caused by Bartonella ... anorexia, ARDS ​• RBC ... severe hemolytic anemia ... Fever #diagnosis #management
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Sickle-cell disease ... Sickle cell disease ... 2) Aplasia - Acute ... co-existent G6PD deficiency ... Crisis #Features #Signs
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... • Severe Liver Disease ... thrombopoietin deficiency ... Treat primary cause ... #treatment #management
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
www.ncbi.nlm.nih.gov/pmc ... presentations and disease ... cardiac output - Acute ... peritonitis - Acute ... 30mmHg) - Severe anemia
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