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hematology differential management algorithm elevation leukemia mds myelodysplastic syndrome treatment acidosis approach calculation chagas chronic cll crisis decrease dermatology disease
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Algorithm Blood ... Loss • Acute ... Deficiency • Aplastic ... #Classification ... #Algorithm #Causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... result from low blood ... #Anemia #oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... - Differential Diagnosis ... • Marrow Aplasia ... Normal RBCs • Acute ... #Algorithm #Causes
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... marrow failure: Aplastic ... Index > 3: • Acute ... blood loss: Trauma ... #differential #diagnosis
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... turnover • Acute ... blood loss • ... Hemolytic anemia ... Increase #Decrease #Diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Crises can be precipitated ... ischaemia. 2) Aplasia ... - Acute worsening ... of the baseline anaemia ... Crisis #Features #Signs
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... • Anemia • Aplastic ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... Pure red cell aplasia ... ’s lymphoma or acute ... #workup #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... ) Classification ... #classification ... #hematology #oncology
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