15 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Diagnosis Algorithm Signs ... Hemolysis: • Autoimmune ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Blood Loss • Acute ... • Anemia of Chronic ... #Classification ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
transform into a RBC ... Index > 3: • Acute ... • Hemolysis: Autoimmune ... , Intrinsic RBC ... Production #Index #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Cold AIHA • Alloimmune ... elliptocytosis - RBC ... immune-complex hemolytic anemia ... • Acute HTR ... Algorithm #Causes #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Vmphocytosis on routine CBC ... 5) Symptoms of anemia ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... • Rare: DAH, acute ... , Anaphylaxis, Acute ... diagnosis #management #hematology ... #oncology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Corticosteroid use • Autoimmune ... 21% had normal WBC ... #CBC #hematology ... #pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - ACS, AKI, acute ... >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
, erythema and WBC ... the time course (acute ... noninflammatory Signs ... Rheumatologic Disease ... Diagnosis #MSK #rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology