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diagnosis differential rheumatology algorithm arthritis causes leukemia management approach classification cll hepatology joint laboratory lymphocytic msk pain systemic thrombocytosis bacilliformis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Infectious: • Acute ... or Chronic Inflammatory ... disorders • Celiac disease ... Iron deficiency anemia
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss • Acute ... RBCs on Smear • Chronic ... • Anemia of Chronic ... Disease • Marrow ... Algorithm #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell disease ... ARUPLabs #Hemolytic #Anemia ... Diagnosis #Algorithm #workup ... #hematology #testing
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... , deficiency anemia ... Vasculitides, IBD, Celiac disease ... • Infections: Chronic
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... deficiencies: Chronic ... kidney disease, ... Index > 3: • Acute ... Production #Index #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Signs and Symptoms ... Proximal limb muscle wasting ... but elevated as disease ... cholangitis #diagnosis #workup ... #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... PT, aPTT(liver disease ... changes), high MCV anemia ... #hematology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune disease ... pericarditis • Hepatic: PBC ... #diagnosis #signs ... #symptoms #testing ... #workup
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
—100-fold with acute ... hepatocytes; in chronic ... liver disease, ... deficiency - Anemia ... anemia; blood loss
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... disease caused ... Presentation ​- Acute ... anorexia, ARDS ​• RBC ... severe hemolytic anemia
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