23 results
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... and petechiae Causes ... #oncology #hematology ... #diagnosis #management
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Hyperviscosity Syndrome ... Leukostasis: • WBC ... death Neutropenic Fever ... : Tumor Lysis Syndrome ... Hyperuricemia • Acute
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
pneumonia • Acute ... infections • Acute ... schistosomiasis • Pyemia ... Non-Infectious Causes ... Brucellosis Faget's Sign
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
count cause hyperviscosity ... - 80% have fever ... - ACS, AKI, acute ... >100k, + lab signs ... TLS #diagnosis #management
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Oroya Fever Hematologic ... disease caused ... anorexia, ARDS ​• RBC ... severe hemolytic anemia ... #diagnosis #management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... : • Common: fever ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Acute febrile ... Episcleritis Signs ... Causes: - Idiopathic ... - CBC may also ... #dermatology #oncology
Cardiorenal Syndrome (CRS) Types
 • Type 1 - Acute CRS: Alteration of renal perfusion is the
Cardiorenal Syndrome ... Types • Type 1 - Acute ... shifts may be in cause ... #CRS #Types #cardiology ... #nephrology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... symptoms are not caused ... : ACUTE, fever, ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms