22 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... elliptocytosis - RBC ... immune-complex hemolytic anemia ... • Acute HTR ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... • Intrinsic RBC ... #anemia
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... Malignant tumors, Acute ... Hemolytic uremic syndrome ... , Disseminated intravascular ... #differential #hematology
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Crises can be precipitated ... The underlying pathophysiology ... 2) Aplasia - Acute ... of the baseline anaemia ... #Features #Signs
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
during severe intravascular ... are seen in acute ... Fatty - Nephrotic syndrome ... ("Maltese cross ... edgarvlermamd - Nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... count cause hyperviscosity ... - ACS, AKI, acute ... >100k, + lab signs ... : • Pathophysiology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... risk-stratification • Risks ... transformation to acute
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... clinical context and signs ... : intravesicular ... Differential #Diagnosis #nephrology ... #causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... malignancy (Especially acute ... protein C and S Pathophysiology ... Treat primary cause ... #Disseminated #Intravascular
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
muscles: “myasthenic crises ... test - Cogan sign ... - Peek sign ... Myasthenia Crises ... aspiration and acute