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diagnosis differential nephrology potassium management high treatment algorithm criticalcare crystalloids diuresis diuretics druginduced encephalopathy excretion foamed function hypertension hypokalemia indications
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Exogenous (KCL ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• NSAIDs • ACE ... infusions) - Metabolic ... Medications 2. ... differential #diagnosis #causes ... potassium #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• NSAIDs • ACE ... infusions) - Metabolic ... Medications 2. ... differential #diagnosis #causes ... potassium #high #nephrology
Major Segments of the Nephron and their Functions - Glomerulus - Formation of glomerular filtrate
filtered Na+/K+/Cl ... filtered Na+ and Cl ... Segments #Function #Pathophysiology ... #Tubules #Table ... #Pharmacology
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
with previously stable ... heart failure, neurologic ... disorders including hypokalemia ... and metabolic alkalosis ... Neurologic disorders
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... Antibiotics (Bactrim, PCN ... only if no clear cause ... Elimination (see Table ... STOP offending medications
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
resistance • Metabolic ... Inhibitors of Na+K+2Cl ... Kidney stones caused ... #Pharmacology # ... Medications #Table
The crusade against “Ab”Normal Saline continues. This is a non-physiologic fluid that can harm our
its Chloride (Cl ... are balanced by Cl ... high amount of Cl ... Hyperkalemia, a ... The high CL- content
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Blood transfusion, Hypercalcemia ... Etiology: • Pathophysiology ... Electrolyte abnormality, Medication ... Drug toxicity, Metabolic
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
Vomiting: urine Na/Cl ... 1.6, low urine Cl ... 0.7, high urine Cl ... with urine Na/Cl ... Other medications
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