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dermatology management lupus differential erythematosus oncology vasculitis classification dermatomyositis druginduced leukemia product reactions signs symptoms syndrome systemic antimda5 antimda5dm antinxp2
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... Glomerulonephritis Myositis(5%) Blood ... signs #symptoms #diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Rare (SSA+ for cutaneous ... Manifestations: Malar rash ... comparison #table #rheumatology ... #diagnosis #management
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
response -> Subacute cutaneous ... hair follicles -> causes ... inflammation on skin ... endothelium) & Decr blood ... pathophysiology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... #Rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... including in children (pediatric ... SLE) 10) When ... #sle #clues #system ... erythematosus #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous ... (blue-purple) rash ... onset [33-74%] • Blood ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Maculopapular rash ... vasculitis (inflamed blood ... #rash #diagnosis ... #rheumatology
Pigmented Purpuric Dermatoses (PPD) - Capillaritis Group of chronic, benign, cutaneous eruptions characterized by the presence of
chronic, benign, cutaneous ... - This iron causes ... brown tint of the rash ... #differential #diagnosis ... #dermatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
- Rash: multiple ... Most common extra cutaneous ... Causes: - Idiopathic ... , breast CA - Hematologic ... neutrophils in the blood
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... Large Vessel: Blood ... vasculitis, and SLE ... #rheumatology #
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