11 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... Pregnancy - TTP/HUS, HELLP ... Bloodman #Pregnancy #Thrombocytopenia ... AFLP #obstetrics #hematology ... #diagnosis #table
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... coagulation defects. 1) HELLP ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison ... #Table
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
, no necrosis HELLP ... features: Hemolysis, Thrombocytopenia ... Disease #Pregnancy #hepatology ... #differential #diagnosis ... #icp #HELLP #AFLP
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... TTP, HUS, DIC, HELLP ... Drug-associated, PCH ... Defects, Drugs, Liver ... #hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
) Differential Diagnosis ... Preeclampsia, HELLP ... #Pregnancy #hepatology ... obstetrics #obgyn #diagnosis ... #management #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... DIC • Severe Liver ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... specifically immune thrombocytopenia ... and M panel Management ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
leukopenia, anemia, and thrombocytopenia ... • Liver function ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
purpura & severe thrombocytopenia ... eruptions, diarrhea, liver ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
purpura & severe thrombocytopenia ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology