20 results
Modified penicillin binding proteins as mechanism of resistance to antibiotics.
Penicillin Binding Proteins (Transpeptidases) cross link peptidoglycan
Streptococcus pneumoniae ... the PBPS so that PCN ... a complicated pneumonia ... or pneumonia in ... Proteins #AMR #PBP #pharmacology
Tigecycline (IV) - Antibiotics Class Overview

Mechanism: Glycylcycline class - structurally related to Tetracyclines (bacteriostatic).  Only
Tigecycline (IV) - Antibiotics ... Class Overview ... sometimes for pneumonia ... #Pharmacology #Antibiotics ... #Review #Overview
Antibiotic treatment durations for first line antibiotics recommended by Public Health England (PHE) guidance
 • Acute
Antibiotic treatment ... Community acquired pneumonia ... Community acquired pneumonia ... primarycare #outpatient #treatment ... #pharmacology #
Aminoglycosides  - Antibiotics Class Overview

Gentamicin, Tobramycin, Amikacin, Streptomycin -30S inhibitor (all IV)
Spectrum: Extremely efficacious vs.
Aminoglycosides - Antibiotics ... Class Overview ... is suspected (pneumonia ... #Pharmacology #Antibiotics ... #Review #Overview
Outpatient Treatment of with Community-Acquired Pneumonia (CAP)
No comorbidities or risk factors for MRSA or Pseudomonas aeruginosa:
Outpatient Treatment ... Community-Acquired Pneumonia ... Community #Acquired #Pneumonia ... #Antibiotics #Treatment ... Management #Guidelines #pharmacology
Flutycosine - Antibiotics Class Overview
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Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
Flutycosine - Antibiotics ... Class Overview ... Severe cryptococcal pneumonia ... #Pharmacology #Antibiotics ... #Review #Overview
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
cause: Aspiration pneumonia ... for Klebsiella pneumonia ... Clindamycin in case of PCN ... treatment until ... Pneumonia • Anaerobic
Macrolides - Erythromycin, Clarithromycin, Azithromycin - Antibiotics Class Overview

50S Ribosomal Inhibitor (PO and IV)
Spectrum: Atypical organisms
Class Overview ... community-acquired pneumonia ... Strep throat in PCN ... Used for MAC treatment ... #Pharmacology #Antibiotics
Sulfonamides - Antibiotics Class Overview

BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic

Spectrum: Wide
Sulfonamides - Antibiotics ... Class Overview ... choice, both for treatment ... #Pharmacology #Antibiotics ... #Review #Overview
Community Acquired Pneumonia (CAP) - Diagnosis and Management

Pneumonia Signs/Symptoms:
 • Confusion/disorientation (LR + 1.9)
 • Cough
Community Acquired Pneumonia ... 96.1% • Empiric antibiotic ... procalcitonin level Treatment ... cultures/nasal PCR ... Diagnosis #Management #treatment