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differential management algorithm causes oncology hemolysis hemolytic abnormal arthritis atlas clinical dermatology dermatomyositis extravascular gout hemophagocytic hepatology hlh hodgkins intravascular
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... Test: Donath-Landsteiner ... test #cold # ... #hematology #diagnosis
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Hemolysis #Hemolytic #Anemia ... Differential #Causes #Workup ... #Hematology #Diagnosis ... GrepMed Recommended Text
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Disorientation, vertigo Diagnostic ... tests - Ice cube ... test, TempTest ... #diagnosis #rheumatology ... #comparison #table
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... : Cold autoimmune ... , Paroxysmal cold ... #differential #diagnosis ... #hematology #microscopy
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH ... anemia, Thalassemias ... Laboratory Tests ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... Agglutination - Cold ... #Algorithm #workup ... #hematology #testing
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... practices that could ... changes), high MCV anemia ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Sickle cell ... AIHA • PCH ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
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