PCL test shoulder diagnosis table management treatment disease syndrome workup lupus rheumatology

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Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
• Associated

Initial screening test ... Treatment: • ... #SLE #Summary #diagnosis ... #rheumatology # ... management

Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
• Epidemiology: 10-180/100,000, Typically Age 20-40, F:M

(SLE) - Diagnosis ... • Immunologic Workup ... life-threatening • Treatment ... Evolution: Chronic disease ... #rheumatology

CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic

Demyelinating Syndrome ... Cerebrovascular Disease ... permeability Diagnosis ... CNS #neurology #rheumatology ... #management #treatment

Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
• Epidemiology: -10% of all lupus cases, drug-dependent,

• Immunologic Workup ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

clinically suspected, tests ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis ... #rheumatology # ... table #ANA

Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
• Young

Positive pathergy test ... is a skin prick test ... Arthritis, AS Treatment ... #diagnosis #management ... signs #symptoms #rheumatology

Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of

Rheumatology Workup ... joint • Systemic lupus ... should be obtained ... #diagnosis #testing ... #Rheumatology

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of

• Systemic lupus ... Liver function tests ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology

Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to

Overwhelming clinical syndrome ... age, however the disease ... • Infection should ... #management #treatment ... #hematology

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