12 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Signs of anemia ... smear Immune-mediated ... Anemias (AIHAs) ... Anemias (AHAs)
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Anemia Intravascular ... bilirubin LDH Peripheral ... smear Haptoglobin ... #Anemia #Laboratory ... #Testing #workup
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Megaloblastic Anemia ... anemia (e.g. ... anemia Sickled ... Analysis #hematology #microscopy ... interpretation #clinical #anemia
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
anemia. ... anemia is characterized ... smear changes are ... #anemia #Hematology ... #Microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... blood smear + DAT ... → Sickle Cell anemia ... anemia (TTP, HUS ... #Anemia #Differential
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
12-13 g/dL, • ANC ... BMP, uric acid, peripheral ... smear, reticulocyte ... ↑ Destruction (hemolysis ... Matthew Ho, MD PhD
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
of macrocytic anemia ... smear, a reticulocyte ... elevated, but anemia ... megaloblastic anemia ... Macrocytosis #Macrocytic #Anemia
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... treatment, her peripheral ... blood smear showed ... BloodSmear #Blood #Smear ... #Microscopy #Auer
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Peripheral Smear ... hematology for workup ... blood loss, Acute hemolysis ... , deficiency anemia ... Matthew Ho, MD PhD
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... the range of Peripheral ... blood smear - Shows ... anemia Indirect ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup