34 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Differential Diagnosis Algorithm ... Matthew Ho, MD PhD ... Differential #Diagnosis #Algorithm ... #hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... Increased red ... #Algorithm #Differential ... Causes #Workup #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... ARUPConsult @ARUPLabs #Hemolytic ... Differential #Diagnosis #Algorithm ... #workup #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... Non-megaloblastic: Liver disease ... Matthew Ho, MD PhD
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Cold Agglutinin Disease ... Matthew Ho, MD PhD ... #Autoimmune #Hemolytic ... Diagnosis #Table #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... differential #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... > 10, no more hemolysis ... • Med duration ... esp if severe disease ... Treatment #management #hematology
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... anemia Sickled red ... cells: Sickle cell disease ... Smear #Analysis #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Differential Diagnosis Algorithm ... • Gaucher's Disease ... Serum Sickness Hemolytic ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Approach to Von Willebrand disease (VWD)

By Matthew Ho, MD PhD @MatthewHoMD

#VWD #Von #Willebrand #VonWillebrand #disease #hematology
Von Willebrand disease ... Matthew Ho, MD PhD ... VonWillebrand #disease ... #hematology #algorithm