43 results
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... DOACs are substrates ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... anticoagulants (DOACs ... vein thrombosis; PE ... filtration rate; DOAC ... Anticoagulation #Management #Hematology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... interruption per ... treatment table ... Perioperative #Management #Treatment ... #pharmacology #
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... → Refer to hematology ... Rebound effect from treatment ... Matthew Ho, MD PhD ... Thrombocytosis #Platelets #Differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Infectious: • Acute ... Non malignant hematologic ... effect following treatment ... Thrombocytosis #Differential
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
incidental DVT or PE ... single subsegmental PE ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Cell Disease Acute ... Supportive with treatment ... of SCD crisis Acute ... Hepatobiliary #hepatology ... #hepatitis #differential
Urticaria (hives): Skin reaction that occurs in response to cold, food allergies, meds, environmental exposures, stings,
infections
Presents as acute ... , focal, red, very ... Images #Clinical #Photo ... #Dermatology #SkinRash
Pharmacotherapy for Migraine Prophylaxis 

Who is indicated for migraine prophylaxis? Patients who experience more than 3
migraine headaches per ... despite appropriate acute ... treatment, or those ... contraindications to acute ... Medications #Table #Pharmacology