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diagnosis hematology oncology algorithm anemia management cd4 hemeonc hemophagocytic hlh icl idiopathic leukemia lymphocytopenia lymphohistiocytosis lymphopenia mds myelodysplasia myelodysplastic normocytic
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Pancytopenia - Differential ... • Toxins • Aplastic ... #Differential # ... #Hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Causes of Neutropenia ... - Differential ... white blood cell aplasia ... #differential # ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... • Marrow Aplasia ... Hypersplenism • Secondary ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... Difficulty breathing • Neutropenia ... and petechiae Causes ... • ↓ WBC • ↓ PLT ... Anemia #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... or functional neutropenia ... count • ↓Hg & PLT ... bone marrow and secondary ... #Leukemia #Hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
underlying primary or secondary ... Heme (lymphoma. aplasia ... ICL #diagnosis #hematology ... #Differential # ... Causes #lymphocytopenia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... • Aplastic Anemia ... Myeloproliferative Disease • Neutropenia ... blood count with differential ... Syndromes #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... STX11, STXBP2 • Secondary ... thrombocytopenia, neutropenia ... Pathophysiology ... Diagnosis #Management #Hematology
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