18 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Biliary Cirrhosis ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... ALP - Biliary ... Hepatocellular injury ... #FunctionTest #LFTs ... Transaminitis #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Highest • Bone • Liver ... - Drugs - Primary ... biliary Cholangitis ... - Other biliary ... Diagnosis #Algorithm #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... phosphatase + ULN ... #Enzymes #LFTs ... #differential #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... , PSC, Alcoholic ... - CBD stone, Biliary ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Biliary: Choledocholithiasis ... , Biliary Stricture ... - Obstruction: Biliary ... diagnosis #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Pathophysiology ... : • Alkaline phosphatase ... obstruction • ALP ... diagnosis #workup #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury → liver ... with alkaline phosphatase ... increase in alkaline phosphate ... #Diagnosis #hepatology ... Transaminitis #LFTs
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
(LFTs) - Normal ... RBCs Alkaline phosphatase ... (AlkP) - Liver, ... hepatocellular injury ... Interpretation #diagnosis #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... T-cell mediated BEC injury ... #Primary #Biliary ... #hepatology