14 results
diagnosis hematology differential causes management aplastic mds myelodysplastic apml cancer chronic cll differentiation gap globulin hematololgy lymphocytic monoclonal myelodysplasia paraproteinemias
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... Chronic Myelogenous Leukemia ... Iron deficiency anemia ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... Expectation • Rx Algorithm ... #diagnosis #oncology ... #hematololgy
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
basophilia, and thrombocytosis ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Hematology #Oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... Differential #Diagnosis #Algorithm
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... transformation to acute leukemia ... Myelodysplastic #Syndrome ... #oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... virus (EBV) • Leukemia ... • ↓ WBC • ↓ PLT ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... • Richter’s Syndrome ... • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... #diagnosis #hematology ... #oncology
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