17 results
diagnosis management oncology differential hemophagocytic lymphohistiocytosis algorithm leukemia acquired activation acute anemia anticoagulation aplastic apml chronic classification cll criteria dermatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Wiskott-Aldrich syndrome ... telomeropathy Cancer ... erythematosus • HLH ... Differential #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... • HLH Labs: ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... Overwhelming clinical syndrome ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... B-LNH), solid cancers ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... adsorption onto cancer ... vonWillebrand #Syndrome ... Diagnosis #Management #treatment ... #hematology #differential
Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease Mild: • Trial of PPI • Trial
Gastroenteritis: Treatment ... strictures Severe + Concern ... for HES: • Hematology ... Gastroenteritis #Treatment ... #management #gastroenterology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Renal Failure Treatment ... fluid overload, PCC ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... syndrome, a search ... for and treatment ... it is often a cancer ... Diagnosis #Management #Hematology
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
Criteria for Sweet Syndrome ... Excellent response to treatment ... count >10 x 10^3/pL ... neutrophils #Sweet #Syndrome ... Criteria #Diagnosis #Hematology
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