8 results
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... aplasia • ITP ... microglobulin Treatment ... ’s lymphoma or acute ... diagnosis #workup #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... transformation to acute ... Allogeneic stem cell ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Acute leukemias ... ALL (Acute Lymphoblastic ... lymphoid organs When Cancer ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
number of CD34+ cells ... • ↓ WBC • ↓ PLT ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
• Marrow Aplasia ... RA, SLE, PRV, Chronic ... Normal RBCs • Acute ... , Target Cells ... Inflammation • Cancer
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
marrow failure: Aplastic ... infiltration (e.g. cancer ... Index > 3: • Acute ... defects (e.g. sickle cell ... Production #Index #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... • Induce blast cell ... fluid overload, PCC ... #oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Causes • Anemia • Aplastic ... Marrow Failure • Chronic ... factor (GCSF) treatments ... Syndromes #diagnosis #hematology ... #oncology