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diagnosis management differential algorithm injury leukemia aki anemia aplastic apml causes chronic classification cll differentiation gap globulin hemophagocytic hlh kidney
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Acute Kidney Injury ... change disease • Hematologic ... malignancies Treatment ... cyclophosphamide) #Acute ... #Oncology #Differential
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... transformation to acute ... Allogeneic stem cell ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... microglobulin Treatment ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... obstruction, HELLP Syndrome ... Disease, Sickle Cell ... Pancreatic Pseudocyst, Cancer ... #algorithm #hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... • Induce blast cell ... diagnosis #management #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... • ↓ WBC • ↓ PLT ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
myeloma • Plasma cell ... changes (POEMS syndrome ... ovarian tumors, lung cancers ... gastric tumors • Hematology ... differential #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... it is often a cancer ... Treatment Approach ... Diagnosis #Management #Hematology ... #HemeOnc
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... current treatment ... clonal evolution to acute ... with repeated red cell ... #algorithm #hematology
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