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diagnosis hematology differential management workup algorithm ana antibody antinuclear blood comparison disorders nuclear patterns product transfusion apml biliary bloodsmear borrelia
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody Testing ... pattern: - PBC ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... differential #diagnosis #rheumatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
INDICATIONS FOR TESTING ... for secondary causes ... eosinophilia (common causes ... allergy, drug reaction ... Differential #diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... 30-65 years PBC ... intralobular bile ducts causes ... Proximal limb muscle wasting ... diagnosis #workup #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... for decreased PLT ... smear, HIV/HCV testing ... for decreased PLT ... #Workup #hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
Polycythemia - Acquired Causes ... Hypoxia-driven: Cardiac/pulmonary ... Paraneoplastic (e.g., RCC ... , HCC, uterine fibroids ... Diagnosis #Algorithm #hematology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
pericarditis • Hepatic: PBC ... calcinosis • Pulmonary ... disease), PAH (pulmonary ... Scleroderma #SSc #rheumatology ... signs #symptoms #testing
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
- Transfusion Reactions ... without other cause ... , and CXR with pulmonary ... #Transfusion #Reactions ... #hematology #diagnosis
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... false negatives on testing ... more likely to cause ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... Causes purpura & ... TRALI): Leading cause ... false negatives on testing ... diagnosis #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Imaging: CXR- pulmonary ... fluid overload, PCC ... diagnosis #management #hematology
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