13 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody Testing ... pattern: - PBC ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... differential #diagnosis #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
) - Summary PBC ... intralobular bile ducts causes ... Proximal limb muscle wasting ... cholangitis #diagnosis #workup ... #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... for decreased PLT ... smear, HIV/HCV testing ... for decreased PLT ... #Workup #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... 1,500 cells/µL Workup ... for secondary causes ... eosinophilia (common causes ... Differential #diagnosis #hematology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
pericarditis • Hepatic: PBC ... calcinosis • Pulmonary ... Scleroderma #SSc #rheumatology ... signs #symptoms #testing ... #workup
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm

Elevated Hemoglobin:
 • Males: Hb > 16.5 g/dL/HCT ≥ 49%
 •
Polycythemia - Acquired Causes ... Hypoxia-driven: Cardiac/pulmonary ... Paraneoplastic (e.g., RCC ... , HCC, uterine fibroids ... Diagnosis #Algorithm #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Imaging: CXR- pulmonary ... fluid overload, PCC ... diagnosis #management #hematology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody Testing ... pattern: • SSc, PBC ... dots pattern: • PBC ... Antinuclear #Antibody #Testing ... differential #diagnosis #rheumatology
Fluid Responsiveness and Fluid Tolerance Testing - OnePager Summary
Fluid resuscitation can be beneficial when required or
Fluid Tolerance Testing ... Pulmonary Artery ... measurement of CO via a PAC ... cardiac output causes ... • PULMONARY A