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diagnosis differential erythematosus lupus infectiousdiseases signs sjogrens summary symptoms acidosis activation adultonset antibodies aosd associations autoantibodies behcet bloodsmear borrelia cardiology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
, autoimmune hepatitis ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... La) - Sjogren's syndrome ... diagnosis #table #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
block • Sjogren syndrome ... polymyositis overlap syndrome ... Treatment: • ... Summary #diagnosis #rheumatology ... #management
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
accompanies other autoimmune ... diseases • In ... biliary cirrhosis (PBC ... ), or with systemic ... erythematosus (SLE
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Disease (AOSD) ... likely conditions (autoimmune ... episode (30%) Systemic ... #rheumatology #diagnosis ... #management #treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... arthritis, adult-onset Still ... • Non-autoimmune ... rheumatologic diseases ... Antiribosomal P, APLA, PAC
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Cerebrovascular Disease ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... Oral aphthae : SLE ... Arthritis, AS Treatment ... #diagnosis #management ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... disease • Systemic ... erythematosus [SLE ... Treatment: • Corticosteroids ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
solid cancers • Autoimmune ... diseases: SLE++ ... +, Adult-onset Still ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... overlaps with RA, SLE ... Adenocarcinoma Treatment ... #Rheumatology # ... Diagnosis #Management
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