10 results
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Hematologic disorder ... marrow plasma cells ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... tubulopathy • Monoclonal ... #AKI #Cancer #Oncology ... #Differential # ... Diagnosis #Classification
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Fatigue • Acute ... Lymphocytes) - Monoclonal ... Reed-Sternberg Cells ... Algorithm #Causes #Hematology ... #Oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... - Differential ... Treated Like Acute ... #Classification ... pathophysiology #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Release from blast cells ... • Induce blast cell ... initiation • Differential ... fluid overload, PCC ... #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Organomegaly+↑RBC/plt ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
myeloma • Plasma cell ... Viral infections (acute ... Connective tissue disorders ... inflammation (acute ... Gap #ProteinGap #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... : • Acute cutaneous ... permanent alopecia Differential ... Angioimmunoblastic T-cell ... : • Chronic B-cell
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... -95% of cases) Classification ... Immunohistochemical studies (to differentiate ... lymphoma #diagnosis #classification ... #hematology #oncology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
Biopsy: Solitary disorder ... tissue composed of monoclonal ... UPEP, Serum IFE, FLC ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology