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differential testing ana antinuclear autoimmune comparison nuclear patterns altered ams anemia antibodies antinxp2 antinxp2dm associations challenges cytoplasmic dermatology dermatomyositis diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... biliary cirrhosis (PBC ... disease Endomyseal antibody ... Associations #diseases #diagnosis ... #table #rheumatology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... LDH • Anti-RBC autoantibodies ... 2) LOOK FOR a cause ... #management #treatment ... #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... #differential #diagnosis ... #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... pattern: • SSc, PBC ... dots pattern: • PBC ... #differential #diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
months) and of autoantibodies ... Usual therapeutic management ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Acute Altered Mental Status - Rapid Response Management 1) Ask while en route: vitals, hyper/hypoactive, POC glucose,
Rapid Response Management ... hyper/hypoactive, POC ... the underlying cause ... mental #status #Management ... #criticalcare #
Fluid Responsiveness and Fluid Tolerance Testing - OnePager Summary Fluid resuscitation can be beneficial when required or
measurement of CO via a PAC ... cardiac output causes ... Tolerance #testing #diagnosis ... #criticalcare # ... comparison #challenges #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... Muscle atrophy may cause ... levels • NXP-2 antibody ... Dermatomyositis #diagnosis ... #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Mechanic's hands Autoantibodies ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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