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differential ana antinuclear hematology nuclear patterns testing anemia antibodies antinxp2 antinxp2dm aplastic apml autoantibodies autoimmune cytoplasmic dermatology dermatomyositis differentiation diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... biliary cirrhosis (PBC ... disease Endomyseal antibody ... #diseases #diagnosis ... #table #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... #differential #diagnosis ... #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
opacities • Diagnosis ... • Differential Diagnosis ... fluid overload, PCC ... #management #hematology ... #oncology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... pattern: • SSc, PBC ... dots pattern: • PBC ... #differential #diagnosis ... #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... • ↓ WBC • ↓ PLT ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Muscle atrophy may cause ... levels • NXP-2 antibody ... • Myoglobin Association ... Dermatomyositis #diagnosis ... #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... (also seen in association ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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