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diagnosis differential rheumatology antinuclear nuclear patterns anemia antibodies aplastic apml associations autoantibodies cytoplasmic dermatology differentiation diseases gap globulin monkeypox mpox
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Testing - Nuclear ... : - PBC, SSc ... , PBC/SSc OS, PBC ... #Testing #Nuclear
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... disease Endomyseal antibody ... diagnosis #table #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear ... pattern: • SSc, PBC ... dots pattern: • PBC ... ARUPConsult @ARUPLabs #ANA
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... fluid overload, PCC ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Management Summary ... Prevalence: 1-2 cases ... autoimmune response ... disorders • Testing ... antibody that works
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... gastric tumors • Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
petechiae Causes ... • ↓ WBC • ↓ PLT ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
disease that is caused ... • Genital, anal ... antiorthopoxvirus IgM antibody ... MPOX #Diagnosis #Management ... #Dermatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
• Anti-NXP2 (ANA ... -1 antibodies (ANA ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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