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diagnosis differential algorithm hepatology rheumatology ana antibody antinuclear hepatitis injury liver nuclear patterns testing cytoplasmic differentiation erythematosus extravascular gap globulin
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... : Autoimmune hepatitis ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SSc, PBC ... pattern: - PBC ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... SjS, SLE, RA, PBC
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Ischemia • Autoimmune ... • Drugs • AIH ... Bile Ducts • PSC ... Duct Stone • Biliary ... Diagnosis #Algorithm #Causes
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... fluid overload, PCC ... Differentiation #Syndrome #APML ... #diagnosis #management ... #hematology #oncology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... subclinical disease to acute ... been reported (eg AIH-PBC ... #Diagnosis #Management ... #Hepatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • Alloimmune ... • PCH ... anemia • Acute ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... : Blast crises ... /Cytopenias • AIHA ... #Leukemia #Hematology ... #Oncology #Diagnosis
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
• SLE, SSc, AIH ... pattern: • SSc, PBC ... dots pattern: • PBC ... conditions • Sp-100, PML ... differential #diagnosis #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Viral infections (acute ... Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... inflammation (acute
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