9 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... AIHA • Anemia ... 2) LOOK FOR a cause ... #management #treatment ... #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... - SLE, SSc, AIH ... , PBC/SjS OS ... #differential #diagnosis ... #rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
common in SLE, autoimmune ... , Anti-gp210 - Primary ... biliary cirrhosis (PBC ... Associations #diseases #diagnosis ... #table #rheumatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
- Differential Diagnosis ... • Ischemia • Autoimmune ... • Drugs • AIH ... Bile Ducts • PSC ... #Algorithm #Causes
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... been reported (eg AIH-PBC ... , AIH diagnosis ... #Diagnosis #Management ... #Hepatology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
• SLE, SSc, AIH ... pattern: • SSc, PBC ... dots pattern: • PBC ... #differential #diagnosis ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... assessment+++ Primary ... solid cancers • Autoimmune ... #management #treatment ... #summary #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... + distinctive primary ... /Cytopenias • AIHA ... #Leukemia #Hematology ... #Oncology #Diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... disease • Non-autoimmune ... the context of primary ... Antiribosomal P, APLA, PAC ... : • AIHA 10% •