13 results
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Vasculitis 1 ... characterized into 3 types ... (type l) : Vascular ... (types II and Ill ... #Rheumatology #
Treatment of Non-hepatitis C virus Cryoglobulinemia Vasculitis - French Vasculitis Study Group

MONOCLONAL CRYOGLOBULINEMIA (TYPE 1) 
IgM
Vasculitis - French ... Vasculitis Study ... (TYPE 1) IgM ... (TYPES II AND III ... #Rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... Types: • Type ... #classification ... #rheumatology # ... vasculitis
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
vasculitis Associated ... neuropathy • Type ... II cryoglobulinemia ... #Vasculitis #Management ... #Rheumatology #
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia ... Classification ... MatthewHoMD #Cryoglobulinemia ... #Classification ... #Types #hematology
Vasculitis - Break down based on vessel size 
Distribution of vessel involvement by large vessel vasculitis,
Vasculitis - Break ... by large vessel vasculitis ... can affect any type ... #Diagnosis #Rheumatology ... Medium #Large #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis and Vasculitides ... ANCA +MPO) • Cryoglobulinemic ... Low levels mixed cryoglobulinemia ... differential #diagnosis #rheumatology ... #classification
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Divided Into Two Types ... malignancies, vasculitis ... sensitivity • Painful ... reticularis • Painful ... Cryofibrinogenemia #diagnosis #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... purpura (16%) • Painful ... purpura • Mixed cryoglobulinemia ... Granulomatous vasculitis ... rash #diagnosis #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Immunotactoid GN & Cryoglobulinemic ... Organomegaly+↑RBC/plt ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic ... Paraproteinemias #Hematology