17 results
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered ... Disease Vascular System ... #Causes #Hematology
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm
Congenital Anomaly / Disorder:
 •
Causes of Sudden ... Congenital Anomaly / Disorder ... • Metabolic Disorders ... Sudden Infant Death Syndrome ... #Causes #Peds #
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
of Systemic Lupus ... Demyelinating Syndrome ... , Seizure disorders ... autoantibodies that will cause ... inflammation, leading
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
Mucous Membrane Disorder ... Differential Diagnosis Algorithm ... Stevens-Johnson Syndrome ... necrolysis - Systemic ... #causes
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... • Nephrotic syndrome ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm ... #causes
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... , leading to the ... • They can cause ... Cryoglobulins Cause ... (e.g. systemic
Restrictive Cardiomyopathy - Diagnosis and Causes
Clinical: Dyspnea, Exercise Intolerance, ↑ "Right Sided-Symptoms" (ascites, hepatomegaly, ↑↑peripheral edema)
Physical
, ↑↑peripheral edema ... Hyper-eosinophilc Syndrome ... Cardiomyopathy, Systemic ... Sarcomeric Protein Disorders ... differential #cardiology #algorithm
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) • Endocrine disorders ... lower extremity edema ... proteinuria, dependent edema ... • May involve PNS
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
• Presence of systemic ... Marfan syndrome, ... #Bleeding #Disorders ... #History #peds ... pediatrics #diagnosis #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Paradoxical spontaneous bleeding ... cryoglobulinemia Associated Disorders ... processes: • Systemic ... cryoglobulins • Negative causes ... Antiphospholipid syndrome