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diagnosis rheumatology differential dermatology lupus management thrombocytopenia vasculitis aortitis bruising classification cns cryoglobulinemia cryoglobulins mucousmembranes naildisorders neurology pediatrics purpura secondary
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
of Systemic Lupus ... Erythematosus ( ... Demyelinating Syndrome ... autoantibodies that will cause ... #SLE #CNS #neurology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Malignancy (e.g. hematologic ... lower extremity edema ... proteinuria, dependent edema ... • May involve PNS
Mucous Membrane Disorder - Differential Diagnosis Algorithm Erosions/Ulcers/Blisters - Primary Dermatologic Diseases •
Mucous Membrane Disorder ... Differential Diagnosis Algorithm ... necrolysis - Systemic ... lupus erythematosus ... #causes
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... Arthritis (RA), Systemic ... lupus erythematosus ... (SLE), Sarcoidosis ... Cancer, Histiocytic disorders
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... (e.g. systemic ... lupus erythematosus
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Abnormality • SLE ... • Nephrotic syndrome ... Differential #Diagnosis #Algorithm ... #causes
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... thrombocytopenia) - SLE ... (systemic lupus ... erythematosus) ... #peds #pediatrics
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... ischemia • Skin: Erythematous ... tract, and often causes ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
, including systemic ... lupus erythematosus ... (SLE), Sjögren’ ... histopathologic changes in LNs ... and the systemic
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