19 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... hemoglobinuria (PNH ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... • PCH • PNH ... anemia • ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Renal Disease, Liver ... Reticulocytosis • Liver ... #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
-100): • Non-hemolytic ... , CKD • Hemolytic ... PK, HbC, HbSS, PNH ... Non-megaloblastic: Liver ... Differential #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... : • Liver disease ... #Anemia #Differential ... classification #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects, Drugs, Liver ... Disease, PNH ... Defects: Sickle cell anemia ... Differential #Diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... deficiency • Liver ... deficiencies - PNH ... Differential #Diagnosis #hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
out additional causes ... and hematologic ... If other causes ... algorithm #diagnosis #management ... #hepatology #gastroenterology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
Inherited Non-hemolytic ... or liver injury ... and stress may cause ... Congenital #bilirubin #hepatology ... #diagnosis #gastroenterology