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diagnosis differential aflp hellp obstetrics pregnancy gastroenterology hemolysis hepatitis table thrombocytopenia ttphus algorithm anemia arterial bariatric bilirubin bypass common complications
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... uremic syndrome ... hemoglobinuria (PNH ... differential #diagnosis #hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
TTP/HUS, HELLP Syndrome ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... AFLP #obstetrics #hematology ... diagnosis #table #comparison
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Defects, Drugs, Liver ... Disease, PNH ... Differential #Diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... deficiency • Liver ... deficiencies - PNH ... Differential #Diagnosis #hematology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
necrosis HELLP Syndrome ... (Hemolysis, Elevated ... clinical features: Hemolysis ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... • Hemolysis ... diagnosis #algorithm #hepatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... Amyloidosis (CVS+PNS ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Inherited Non-hemolytic ... without evidence of hemolysis ... or liver injury ... and stress may cause ... Congenital #bilirubin #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... , Ischemic Liver ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
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