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diagnosis differential abnormal aptt arterial intravascular management prolonged pt thrombosis treatment venous bleeding bruising clots dermatology dic embolism encephalopathy extravascular
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... endocarditis) - Disseminated ... intravascular coagulation ... neoplasms - PNH ... Diagnosis #clots #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treat primary cause ... bleeding #DIC #Disseminated ... #diagnosis #causes ... treatment #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ): - Disseminated ... intravascular coagulation ... differential #diagnosis #hematology ... #anemia
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... Causes of false- ... amyloidosis Other causes ... MGUS #diagnosis #hematology ... #oncology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... - Hemolytic anemia ... deficiencies - PNH ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes ... pathophysiology #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... hemorrhage • Disseminated ... #differential #hematology ... #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... e.g. heparin ... Disseminated intravascular ... #differential #hematology ... #coagulation
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Can Feature A Monoclonal ... Amyloidosis (CVS+PNS ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Hepatic Encephalopathy Treatment • Lactulose: - Oral liquid, 30-45mL 2-4x/day, titrated to 2-4
Hepatic Encephalopathy ... swallow) - Via enema ... For refractory cases ... EricsMedicalLectures/ #Hepatic ... Treatment #management #hepatology
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