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differential coagulation abnormal management pt algorithm arterial intravascular thrombosis treatment venous anemia ascites bleeding bruising checklist cirrhosis clots dermatology dic
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
K Antagonists, Heparin ... to identify the cause ... of Prolonged APTT ... #prolonged #diagnosis ... #hematology #evaluation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT • Prolonged ... #Differential #Diagnosis ... #Algorithm #Causes ... #Hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... hemorrhage • Disseminated ... #Prolonged #Causes ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #management #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... - Differential Diagnosis ... endocarditis) - Disseminated ... neoplasms - PNH ... #clots #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... is prolonged, but ... mixing study (aPTT ... normal in mild cases ... Management #treatment #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia - Disseminated ... pathophysiology #hematology ... #differential #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... anemia): - Disseminated ... hemoglobinuria (PNH ... #hematology #anemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... deficiencies - PNH ... Cholesterol emboli • Septic ... #Differential #Diagnosis ... #hematology #rheumatology
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