18 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... PT (INR), Normal ... PTT, Normal PT ... Diagnosis #Algorithm #Causes ... #Hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... 100mg/dL) - Heparin ... #diagnosis #causes ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... (DIC) c. ... Jcortesizaguirr #Abnormal ... #differential #hematology ... #coagulation
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... intravascular coagulation ... neoplasms - PNH ... Diagnosis #clots #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #differential #hematology ... #coagulation
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... Defects: • DIC ... deficiencies - PNH ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
to Evaluate an Abnormal ... K Antagonists, Heparin ... to identify the cause ... ISNeducation #Abnormal ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Drug-induced AIHA - Abnormal ... • PCH • PNH ... • MAHA (TTP, DIC ... #Hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... fatigue (e.g. prolonged ... succenturiate lobe • Abnormal ... (DIC) • Anti-coagulation ... agents (e.g. heparin
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... hemoglobinuria (PNH ... differential #diagnosis #hematology