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diagnosis differential treatment algorithm abnormal aptt coagulation syndrome anticoagulation cancer classification dermatology doac encephalopathy malignancy pt rheumatology vte anemia antinxp2
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Artifactually Prolonged ... K Antagonists, Heparin ... to identify the cause ... of Prolonged APTT ... #diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... Pre-analytical cause ... e.g. heparin ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Diagnosis for a Prolonged ... Causes include : ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... old, ~10,000 new cases ... acute leukemia Management ... #treatment #hematology ... #oncology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
• Secondary Causes ... deficiencies - PNH ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology ... #rheumatology #
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis. Currently, edoxaban and rivaroxaban are the only
molecular weight heparin ... Anticoagulation #Management ... #Hematology #Oncology
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 Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
cardiac valves (septic ... Hyperhomocysteinemia - Heparin-induced ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... disease) • aPTT is prolonged ... normal in mild cases ... Chronic Management ... #treatment #hematology
Hepatic Encephalopathy - Diagnosis and Management Summary Definition: • Alteration in brain function manifested by neuropsychiatric symptoms
Hepatic Encephalopathy ... Diagnosis and Management ... neuropsychiatric symptoms • Caused ... LizzieAbyMD #Hepatic ... #treatment #hepatology
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