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diagnosis differential management abnormal algorithm aptt encephalopathy gastroenterology intravascular prolonged pt rheumatology activation alkaline alp arterial bariatric bleeding bruising bypass
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
DIC • Severe Liver ... Treat primary cause ... #diagnosis #causes ... #treatment #management ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... deficiency • Liver ... deficiencies - PNH ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
Acute sickle cell hepatic ... Supportive with treatment ... hepatomegaly and anemia ... Liver transplant ... Hepatobiliary #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... hemoglobinuria (PNH ... differential #diagnosis #hematology ... #anemia
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... #differential #hematology ... #coagulation
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... disease, Hepatic ... presentation: Hepatic ... Diagnosis #Algorithm #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... and other causes ... pathophysiology #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... #differential #hematology ... #coagulation
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
diagnosis and treatment ... and hematologic ... If other causes ... hemochromatosis; HIC, hepatic ... diagnosis #management #hepatology
Hepatic Encephalopathy Treatment • Lactulose: - Oral liquid, 30-45mL 2-4x/day, titrated to 2-4
Hepatic Encephalopathy ... Treatment • Lactulose ... swallow) - Via enema ... For refractory cases ... #management #hepatology
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