13 results
diagnosis management leukemia differential hemeonc lymphocytic rheumatology algorithm apml arterial classification coagulation dic differentiation disseminated embolism emergencies fungal hemophagocytic hlh
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Headaches, bone pain, fever ... Lymphadenopathy • HSM • Fevers ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphadenopathy • Fevers ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... ) B symptoms → fevers ... #Leukemia #oncology ... #hematology #hemeonc
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
considered in all ... Hyperhomocysteinemia - Heparin-induced ... - Disseminated intravascular ... coagulation and other causes ... pathophysiology #hematology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... • Bacteremia/Septic ... jirovecii • CNS ... Bronchitis • Chronic ... #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... +++ (Plt, Hb), Hepatic ... lymphoma (DLBCL, intravascular ... Drugs, Unknown cause ... Treatment: •
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
• Induce blast cell ... Subacute-Acute: • Common: fever ... myalgias, HoTN, edema ... diagnosis #management #hematology ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... syndrome): - Hematologic ... (disseminated intravascular ... Treat underlying cause ... ± tocilizumab; call
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... infection • Cough, fever ... MC: CNS CSF: • ... • Isolated fever ... anidulafungin) • Intravascular
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