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management algorithm differential lymphadenopathy syndrome diffuse localized mds myelodysplastic rheumatology anemia antinxp2 antinxp2dm aplastic cell chronic classification cll coagulation dermatology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... • Neoplastic (Leukemia ... ) #Diffuse #Focal ... Lymphadenopathy #LAD ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Lymphadenopathy #LAD ... #Algorithm #Causes ... #Hematology #Oncology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... - Differential Diagnosis ... #Localized #Focal ... Lymphadenopathy #LAD ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... transformation to acute leukemia ... only curative treatment ... #Management #treatment ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... -> AML: Blast crises ... count ↑ PLT • ↑ PBS ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... phenomenon CLL Diagnosis ... microglobulin Treatment ... #diagnosis #workup ... #oncology #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... Treat primary cause ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Better call hematology ... JAK2 V617F) and MPNs ... #Algorithm #workup ... #hematology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Prevalence: 1-2 cases ... positive in 2/3 of pts ... antibody that works ... Axial dystonia, Focal ... #Management #treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Hairy Cell Leukemia ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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