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diagnosis management aids antimicrobials coagulation csf dic differential disseminated emergencies hemeonc hemophagocytic hiv hlh infections intravascular leukemia lymphohistiocytosis neurology oncologic
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
CNS Infection in ... HIV-Associated CNS ... Antimicrobial treatment ... Demyelinating disease caused ... opportunistic #InfectiousDiseases
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thromboembolism (7%) • CNS ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
published looking at CNS ... treat susceptible CNS ... of CNS infections ... #Penetration #CNS ... #Pharmacology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... leukostasis syndrome: CNS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Lymphohistiocytosis (HLH) Treatment ... (depending on CNS ... autoimmune disease, treatment ... Options for severe cases ... #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... Adenocarcinoma Treatment ... lubricants • Pharmacologic
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... syndrome): - Hematologic ... Treat underlying cause ... ) - Symptoms: CNS ... ) - Symptoms: CNS
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