13 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... , HCV - Alcohol ... plateletcount), peripheral blood ... not required in all ... #Workup #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... deficiency) • HIT ... Treat primary cause ... #treatment #management ... #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
→ Calculate 4T score ... • If 4T score ... Management: • D/c all ... Diagnosis #Management #Treatment ... #Hematology #HemeOnc
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Score • CML -> ... AML: Blast crises ... Pruritis after hot ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Hematological: - HIT ... considered in all ... Heparin-induced thrombocytopenia ... coagulation and other causes ... pathophysiology #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... membrane into the CNS ... deficiency • blood ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
of high parity blood ... Pathophysiology: 2 hit ... without other cause ... with pulmonary edema ... Transfusion #Reactions #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... involve one, two, or all ... IDUS) • Immune Thrombocytopenia ... arsenic compounds, alcohol ... Syndromes #diagnosis #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
infections/fevers • Thrombocytopenia ... and petechiae Causes ... aplastic anemia Treatment ... result from low blood ... Anemia #oncology #hematology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... exclude other causes ... with chest x-ray, blood ... HIV, TB - Multiorgan ... Management #Algorithm #hepatology