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diagnosis treatment reactions hemophagocytic lymphohistiocytosis product sle transfusion activation antinxp2 antinxp2dm associations cerebritis classification cns coagulation connectivetissuediseases ctild dermatology dermatomyositis
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... SLE : systemic lupus ... #Differential #Comparison ... #Table #Pulmonary ... #Rheumatology #
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #neurology #rheumatology ... cerebritis #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... • Systemic lupus ... nervous system (CNS ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... • Autoimmune diseases ... Adult-onset Still disease ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
(depending on CNS ... or autoimmune disease ... for refractory disease ... #Treatment #management ... #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Usual therapeutic management ... Evolution: Chronic disease ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
of high parity blood ... without other cause ... with pulmonary edema ... Transfusion #Reactions #hematology ... #table
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Workup: • Full Blood ... marrow biopsy - if blood ... number of sites of disease ... classification #hematology ... #oncology #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... donors (due to anti-HLA ... Transfusions #diagnosis #management ... #hematology #reactions
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