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diagnosis rheumatology differential treatment dermatology cardiology pharmacology algorithm anemia antinxp2 antinxp2dm arterial atlas basics capillary cardiomyopathy cerebritis chf clinical cns
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... hemoglobinuria (PNH ... #diagnosis #hematology
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Clarkson’s Disease ... pain, Diffuse edema ... risk of pulmonary edema ... Breillat #Clarksons ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... hemangiomata, clubbing Clarkson ... Amyloidosis (CVS+PNS ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... • Nephrotic Syndrome ... - Disseminated intravascular ... coagulation and other causes ... pathophysiology #hematology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
disequilibrium syndrome ... irrigation • Management ... Kidney stones caused ... • Liddle syndrome ... #Medications #Table
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... #neurology #rheumatology ... cerebritis #diagnosis #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
• Facial Edema ... in 70% of cases ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis ... #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... #Rheumatology # ... Diagnosis #Management
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