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management diagnosis fungal cerebritis clinical coagulation coccidioidomycosis crypto cryptococcal dic disseminated erythematosus hemophagocytic hlh infections infectiousdiseases intravascular lupus lymphohistiocytosis meningitis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thromboembolism (7%) • CNS ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Lymphohistiocytosis (HLH) Treatment ... (depending on CNS ... autoimmune disease, treatment ... Options for severe cases ... #management #hematology
Coccidioidomycosis (Coccidioides): Valley Fever - Summary Sheet • Morphology • Geography, Reservoir and Mode of Transmission
Coccidioidomycosis (Coccidioides ... periods after rain ... involvement in >95% of cases ... tissue, skeleton, CNS ... nodule/cavity: no treatment
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... especially the CNS ... MC: CNS CSF: • ... • Sinusitis • Brain ... • Serology for Coccidioides
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
low glucose) CNS ... Nausea & vomiting ... Standard treatment ... meningitis #T2 #MRI #Brain ... #clinical #radiology
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